Small noncoding microRNAs (miRNAs)
are important regulators of post-transcriptional gene regulation and have
altered the prevailing view of a linear relationship between gene and protein
expression. Aberrant miRNA expression is an emerging theme for a wide variety
of diseases, highlighting the fundamental role played by miRNAs in both
physiological and pathological states. The identification of stable miRNAs in
bodily fluids paved the way for their use as novel biomarkers amenable to
clinical diagnosis in translational medicine. Identification of miRNAs in
exosomes that are functional upon delivery to the recipient cells has
highlighted a novel method of intercellular communication. Delivery of miRNAs
to recipient cells via blood, with functional gene regulatory consequences, opens
up novel avenues for target intervention. Exosomes thus offer a novel strategy
for delivering drugs or RNA therapeutic agents. Though much work lies ahead,
circulating miRNAs are unequivocally ushering in a new era of novel biomarker
discovery, intercellular communication mechanisms, and therapeutic intervention
strategies.
Source: Circulating microRNAs as
biomarkers, therapeutic targets, and signaling molecules. Ajit SK. Sensors (Basel
Free paper available at:
Aucun commentaire:
Enregistrer un commentaire