The U.S. Food and
Drug Administration recently approved Cometriq (cabozantinib) to treat
medullary thyroid cancer that has metastasized.
Medullary thyroid cancer
develops in cells in the thyroid gland that make a hormone called calcitonin,
which helps maintain a healthy level of calcium in the blood. This type of
cancer may occur spontaneously or in families with certain genetic mutations
that result in one or more cancers of the endocrine system, including the
thyroid gland. About 4 percent of thyroid cancers are medullary thyroid cancer,
making it one of the rarer types of thyroid cancers.
Cabozantinib is a kinase
inhibitor that blocks abnormal kinase proteins involved in the development and
growth of medullary cancer cells.
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