ABSTRACT:
BACKGROUND: People with
lung cancer have substantial symptom burden and more unmet needs than the
general cancer population. Physical activity (PA) has been shown to positively
influence quality of life (QOL), fatigue and daily functioning in the curative
treatment of people with breast and colorectal cancers and lung diseases, as
well as in palliative settings. A randomised controlled trial (RCT) is needed
to determine if lung cancer patients benefit from structured PA intervention.
The Physical Activity in Lung Cancer (PAL) trial is designed to evaluate the
impact of a 2-month PA intervention on fatigue and QOL in patients with
non-resectable lung cancer. Biological mechanisms will also be studied.
METHODS:
A multi-centre RCT with
patients randomised to usual care or a 2-month PA programme, involving
supervised PA sessions including a behavioural change component and home-based
PA. QOL questionnaires, disease and functional status and body composition will
be assessed at baseline, 2, 4 and 6 months follow-up. The primary endpoint is
comparative levels of fatigue between the 2 arms. Secondary endpoints include:
QOL, functional abilities and physical function. Exploratory endpoints include:
anxiety, depression, distress, dyspnoea, PA behaviour, fitness,
hospitalisations, survival, cytokines and insulin-like growth factor levels.
DISCUSSION:
This study will provide
high-level evidence of the effect of PA programmes on cancer-related fatigue
and QOL in patients with advanced lung cancer. If positive, the study has the
potential to change care for people with cancer using a simple, inexpensive
intervention to improve their QOL and help them maintain independent function
for as long as possible.
Source: The
impact of physical activity on fatigue and quality of life in lung cancer
patients: a randomised controlled trial protocol. Dhillon HM, Ploeg HP, Bell
ML, Boyer M, Clarke S, Vardy J (janette.vardy@sydney.edu.au)
. BMC Cancer. 2012 Dec 5;12(1):572.
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