Abstract
OBJECTIVE:
To
evaluate the effect of alcohol cessation on the risk of developing laryngeal
and pharyngeal cancers, combining available evidence in the scientific
literature in a meta-analysis.
METHODS:
A
systematic literature review was conducted, and a meta-analysis was applied on
the retrieved studies. The generalised least squares method was used to
estimate the trend from dose-response data to assess changes in the risks of
laryngeal and pharyngeal cancers after drinking cessation.
RESULTS:
A total
of 9 case-control studies were included in the meta-analysis (4 and 8 estimates
for laryngeal and pharyngeal cancers, respectively). On average, alcohol
drinking cessation was associated with a 2% yearly reduction in the risk of
developing laryngeal and pharyngeal cancers. There was a considerable
heterogeneity between the studies of pharyngeal cancer, but this was mostly due
to two studies. The increased risk of laryngeal and pharyngeal cancers caused
by alcohol was reversible; the time periods until the risks became equal to
those of never drinkers were 36 (95% CI 11-106) and 39 (95% CI 13-103) years,
respectively. Moreover, 5 years of drinking cessation was associated with a
reduction of around 15% in the alcohol-related elevated risk of laryngeal and
pharyngeal cancers.
CONCLUSION:
Although
a long time period is required to completely eliminate the alcohol-related
elevated risk of laryngeal and pharyngeal cancers, a substantial risk reduction
can be seen in the short term (5-10 years), and drinking cessation should
therefore be encouraged to reduce the incidence of these cancers.
Source: Alcohol drinking cessation and the risk of laryngeal
and pharyngeal cancers: a systematic review and meta-analysis. Ahmad Kiadaliri
A (aliasghar.ahmad_kiadaliri@med.lu.se),
Jarl J, Gavriilidis G, Gerdtham UG. PLoS One. 2013;8(3):e58158.
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