Preclinical
studies have suggested that sunitinib accelerates metastases in animals,
ascribing this to inhibition of the vascular endothelial growth factor receptor
or the tumor's adaptation. To address whether sunitinib accelerates tumors in
humans, we analyzed data from the pivotal randomized phase III trial comparing
sunitinib and interferon alfa in patients with metastatic renal cell carcinoma.
The evidence clearly shows that sunitinib was not harmful, did not accelerate
tumor growth, and did not shorten survival. Specifically, neither longer
sunitinib treatment nor a greater effect of sunitinib on tumors reduced
survival. Sunitinib did reduce the tumor's growth rate while administered,
thereby improving survival, without appearing to alter tumor biology after
discontinuation. Concerns arising from animal models do not apply to patients
receiving sunitinib and likely will not apply to similar agents.
Source: Sunitinib does not accelerate tumor growth in patients
with metastatic renal cell carcinoma. Blagoev KB (kblagoev@nsf.gov), Wilkerson J, Stein WD,
Motzer RJ, Bates SE, Fojo AT. Cell Rep. 2013 Feb 21;3(2):277-81.
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