Abstract
The immense increase in availability
of genomic scale datasets, such as those provided by the ENCODE and Roadmap
Epigenomics projects, presents unprecedented opportunities for individual
researchers to pose novel falsifiable biological questions. With this
opportunity, however, researchers are faced with the challenge of how to best
analyze and interpret their genome-scale datasets. A powerful way of
representing genome-scale data is as feature-specific coordinates relative to
reference genome assemblies, i.e. as genomic tracks. The Genomic HyperBrowser
(http://hyperbrowser.uio.no) is an open-ended web server for the analysis of
genomic track data. Through the provision of several highly customizable
components for processing and statistical analysis of genomic tracks, the
HyperBrowser opens for a range of genomic investigations, related to, e.g.,
gene regulation, disease association or epigenetic modifications of the genome.
Source: The Genomic HyperBrowser: an
analysis web server for genome-scale data. Sandve GK, Gundersen S, Johansen M,
Glad IK, Gunathasan K, Holden L, Holden M, Liestøl K, Nygård S, Nygaard V,
Paulsen J, Rydbeck H, Trengereid K, Clancy T, Drabløs F, Ferkingstad E, Kalas
M, Lien T, Rye MB, Frigessi A, Hovig E. Nucleic Acids Res. 2013 Apr 30.
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