Abstract
PURPOSE:
The aims of this study were to
evaluate the clinical significance and potential prognostic value of pregnancy
up-regulated non-ubiquitous calmodulin kinase (PNCK) in clear cell renal cell
carcinoma (ccRCC) patients.
MATERIALS AND METHODS:
The expression of PNCK mRNA was
determined in 24 paired samples of ccRCCs and adjacent normal tissues using
real-time RT-PCR. The expression of PNCK was determined in 248 samples of
ccRCCs and 92 paired samples of adjacent normal tissues by immunohistochemical
analysis. Statistical analysis was performed to define the relationship between
PNCK expression and the clinical features of ccRCC.
RESULTS:
The mRNA level of PNCK was
significantly higher in tumorous tissues than in the adjacent non-tumorous
tissues (p<0.001). An immunohistochemical analysis of 92 paired tissue
specimens showed that PNCK expression was higher in tumorous tissues than in
the adjacent non-tumorous tissues (p<0.001). Moreover, there was a
significant correlation between the PNCK expression and various
clinicopathological parameters such as Fuhrman grade (p = 0.011), tumor size (p<0.001), T
stage (p<0.001) and N stage (p = 0.015). Patients with higher PNCK expression had shorter overall
survival time than those with lower PNCK expression (p<0.001). Multivariate
analysis indicated that PNCK expression was an independent predictor for poor
survival of ccRCC patients.
CONCLUSIONS:
To our knowledge, this is the first
study that determines the relationship between PNCK and prognosis in ccRCC. We
found that increased PNCK expression is associated with poor prognosis in
ccRCC. PNCK may represent a novel prognostic marker for ccRCC.
Source: Increased expression of
pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor
prognosis in clear cell renal cell carcinoma. Wu S, Lv Z, Wang Y, Sun L, Jiang
Z, Xu C, Zhao J, Sun X, Li X, Hu L, Tang A, Gui Y, Zhou F, Cai Z, Wang R (rfwang888@hotmail.com). PLoS One. 2013
Apr 25;8(4):e59936.
Free paper available at:
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