Name (nom) | Code name (nom de code) | Type | Target(s) (Cible(s)) |
| | | |
BMS-901608 HuLuc63 | antibody (anticorps) | SLAM family member 7 (CD2-like receptor activating cytotoxic cells, CD319 antigen), CS1 |
According to National Cancer Institute (NCI) Drug Dictionary, elotuzumab is a humanized monoclonal antibody directed against the human CS1 (CD2 subset 1, CRACC, SLAMF7) antigen with potential antineoplastic activity. Elotuzumab binds to the CS1 antigen, which may trigger antibody-dependent cellular cytotoxicity (ADCC) in cells expressing CS1. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is highly expressed by multiple myeloma cells, but minimally expressed by normal cells.
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