BACKGROUND:
Cyclooxygenase-2
(COX-2) is believed to be an important enzyme in the pathogenesis of colorectal
cancer (CRC). Correlations between the expression of COX-2 with tumor growth
and distant metastasis have become an issue; thus, attention has been paid to
COX-2 as a prognostic factor. Various studies examined the relationship between
COX-2 immunohistochemistry (IHC) overexpression with the clinical outcome in
patients with colorectal cancer, but yielded conflicting results. The
prognostic significance of COX-2 overexpression in colorectal cancer remains
controversial.
METHODS:
Electronic
databases updated to October 2012 were searched to find relevant studies. A
meta-analysis was conducted with eligible studies which quantitatively
evaluated the relationship between COX-2 overexpression and survival of
patients with colorectal cancer. Survival data were aggregated and
quantitatively analyzed.
RESULTS:
We
performed a meta-analysis of 23 studies (n = 4567 patients) that evaluated the
correlation between COX-2 overexpression detected by IHC and survival in
patients with colorectal cancer. Combined hazard ratios suggested that COX-2
overexpression had an unfavorable impact on overall survival (OS) (HR [hazard
ratio] = 1.193, 95% CI [confidence
interval]: 1.02 ∼ 1.37), but not disease free
survival (DFS) (HR = 1.25, 95% CI: 0.99 ∼ 1.50)
in patients with colorectal cancer.
CONCLUSIONS:
Cox-2
overexpression in colorectal cancer detected by IHC appears to have slightly
worse overall survival. However, the prognostic value of COX-2 on survival in
colorectal cancer still needs further large-scale prospective trials to be
clarified.
Source: Prognostic Significance of COX-2 Immunohistochemical
Expression in Colorectal Cancer: A Meta-Analysis of the Literature. Peng L, Zhou Y, Wang Y, Mou H,
Zhao Q (doczq.2008@gmail.com). PLoS One. 2013;8(3):e58891.
Free
paper available at:
Aucun commentaire:
Enregistrer un commentaire