Epithelial to Mesenchymal transition
(EMT) in cancer, a process permitting cancer cells to become mobile and
metastatic, has a signaling hardwire forged from development. Multiple
signaling pathways that regulate carcinogenesis enabling characteristics in
neoplastic cells such as proliferation, resistance to apoptosis and
angiogenesis are also the main players in EMT. These pathways, as almost all
cellular processes, are in their turn regulated by ubiquitination and the
Ubiquitin-Proteasome System (UPS). Ubiquitination is the covalent link of
target proteins with the small protein ubiquitin and serves as a signal to
target protein degradation by the proteasome or to other outcomes such as
endocytosis, degradation by the lysosome or specification of cellular
localization. This paper reviews signal transduction pathways regulating EMT
and being regulated by ubiquitination.
Source : The
ubiquitin-proteasome system and signal transduction pathways regulating
Epithelial Mesenchymal transition of cancer. Voutsadakis IA.
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