Matricellular proteins have been
classified as a family of non-structural matrix proteins capable of modulating
a variety of biological processes within the extracellular matrix (ECM). These
proteins are expressed dynamically and their cellular functions are highly
dependent upon cues from the local environment. Recent studies have shown an
increasing appreciation of the key roles these ECM proteins play within the
tumour microenvironment. Induced by either tumour cells or tumour stromal
components, matricellular proteins initiate downstream signalling events that
lead to proliferation, invasion, matrix remodelling and dissemination to
pre-metastatic niches in other organs. In this review, we summarise and discuss
the current knowledge of the diverse roles these proteins play within the
microenvironment that influences tumour progression and potential for future
therapies targeting the tumour microenvironment.
Source: Matricellular proteins:
priming the tumour microenvironment for cancer development and metastasis. Wong
GS, Rustgi AK
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