vendredi 25 janvier 2013

Press Review (January 26, 2013) – Revue de presse (26 janvier 2013)





Promising Prognostic Marker for Aggressive Breast Cancer
A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of breast cancer. Published in Science Translational Medicine, the study lays the early foundation for predicting which breast cancer patients may develop more aggressive disease and for designing more effective treatments.
In Science Daily

Cancer expert remains to be convinced by breast screening review
Harms from breast cancer screening outweigh benefits if death caused by treatment is included.
In EurekAlert (press release)

SNPs Associated With Breast Cancer Risk Alter Binding Affinity for Pioneer Factor FOXA1
Dartmouth scientists showed that more than half of all the SNPs associated with breast cancer risk are located in distant regions and bound by FOXA1, a protein required for estrogen receptor-α (ER) function according to a paper published in the journal Nature Genetics in November.
In Science Daily (press release)

Personal Epigenetic 'Signatures' Found Consistent in Prostate Cancer Patients' Metastases
In a genome-wide analysis of 13 metastatic prostate cancers, scientists at the Johns Hopkins Kimmel Cancer Center found consistent epigenetic "signatures" across all metastatic tumors in each patient. The discovery of the stable, epigenetic "marks" that sit on the nuclear DNA of cancer cells and alter gene expression, defies a prevailing belief that the marks vary so much within each individual's widespread cancers that they have little or no value as targets for therapy or as biomarkers for treatment response and predicting disease severity.
In Science Daily

Researchers prevent cancer spread by blocking tissue scarring
Researchers at BRIC, University of Copenhagen have shown that the enzyme Lysyl Oxidase (LOX) can create a "scarred" microenvironment that enhances cancer spreading.
In Medical Xpress

Planning for Bacteria in Cancer Patients May Help Hospitals Fight Infections
What cancerous conditions lead to what kinds of bacterial infections? If doctors knew, they could predict which patients would likely benefit from pre-treatment with certain kinds of antibiotics. A University of Colorado Cancer Center study published in this month's issue of the International Journal of Infectious Diseases shows the answer: E. coli and Klebsiella pneumoniae are especially prevalent in patients with lung and GI cancers, more so for Klebsiella if these patients have been treated previously with aminopenicillins.
In Science Daily

Research: Lupus drugs carry no significant cancer risk for patients
People who take immunosuppressive drugs to treat lupus do not necessarily increase their cancer risk according to new research led by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC). This landmark study, which was published in Annals of the Rheumatic Diseases this month, addresses long-standing fears of a link between lupus medication and cancer.
In EurekAlert (press release)

Can Metastasis of Triple-Negative Breast Cancer Be Thwarted?
Researchers have demonstrated how a particularly aggressive type of breast cancer, triple-negative disease, spreads to other parts of the body. The results may lead to new therapies that could treat metastatic breast cancer. The findings are published in Cancer Cell.
By Anna Azvolinsky. In Cancer Network


Informing women on breast cancer overdiagnosis
In a study exploring women's responses to being told about overdiagnosis in breast cancer screening, most women felt the information was important and could enable them to make choices.
In Medical Xpress





Risque accru de cancer du poumon chez les fumeuses
Le risque de mourir d'un cancer du poumon a très fortement augmenté ces dernières décennies chez les femmes qui fument, selon une étude ayant porté sur plus de deux millions d'Américains, rendue publique mercredi.
Dans France24


Pourquoi les gros animaux sont-ils moins sujets au cancer que nous ?
Plus un animal est gros, plus il possède de cellules. Logiquement, on pourrait penser que plus il y a de cellules dans un organisme, plus il y a de risques de contracter un cancer. Pourtant, on constate le phénomène inverse. Cette contradiction, nommée paradoxe de Peto, vient d’être expliquée par un modèle mathématique. Une justification qui ne fait pas l’unanimité.
Par Janlou Chaput. Dans Futura-Sciences

Cancer pancréatique stade IV : une association accroît la survie
Selon les résultats d’une étude multicentrique de phase III, l’association d’Abraxane (nab paclitaxel) et de gemcitabine majore la survie des patients atteints d’une forme avancée de cancer pancréatique.
Dans Le Quotidien du Médecin  

Cancer: Une mortalité en baisse de 20% en 20 ans
C’est le rapport annuel encourageant de l’American Cancer Society, qui porte certes sur les Etats-Unis mais nous donne une tendance non négligeable. Car dans ce seul pays, ce sont en 20 années, 1,2 millions de décès par cancer qui ont été prévenus soit plus de 150.000 pour la seule année 2009. Les 4 cancers « les plus lourds » sont en régression, mais certains cancers poursuivent leur progression, comme le mélanome, le cancer de la thyroïde et du pancréas. Des indications précieuses pour l’ensemble des pays.
Dans Santé Log

Calvitie précoce: Un indicateur de risque de cancer de la prostate?
La science nous livre parfois de curieuses associations mais elles trouvent toujours leur explication. Ici c’est la calvitie précoce, c’est-à-dire vers 40 ans qui est associée à un risque accru de cancer de la prostate. Cette étude australienne, présentée dans Cancer Epidemiology Biomarkers and Prevention qui, précisons-le n’a pas évalué les taux de mortalité, ne doit pas désespérer les hommes jeunes atteint d’alopécie androgénétique, en particulier, rappellent les auteurs, parce que de nombreux cas de cancer de la prostate ne sont pas agressifs.
Dans Santé Log

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