vendredi 26 juillet 2013

Press Review (July 27, 2013) – Revue de presse (27 juillet 2013)

Black-White Divide Persists in Breast Cancer
Breast cancer survival is, over all, three years shorter for black women compared with white women, mostly because their cancer is often more advanced when they first seek medical care, new research shows.
By Tara Parker-Pope. In New York Times (blog)

Smart Knife Sniffs Out Cancer Cells.
When surgeons can't determine the edges of a tumor, it's a problem. Cut too much, and they risk hurting the patient. Cut too little, and they may leave stray cancer cells behind. Now, researchers have developed a surgical knife that can sniff the smoke made as it cuts tissue, almost instantly detecting whether cells are cancerous or healthy.
By Jocelyn Kaiser. In Science AAAS                

The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis
In the study, we analyzed role of p53 in predicting outcome in visceral metastasis breast cancer (VMBC) patients. 97 consecutive VMBC patients were studied. P53 positivity rate was 29.9%. In the p53-negative group, median disease free survival (DFS), and time from primary breast cancer diagnosis to death (OS1), time from metastases to death (OS2) were 25, 42.5, and 13.5 months, respectively. In the p53-positive group, they were 10, 22, and 8 months, respectively. Statistically significant differences in DFS and OS1 were detected between the p53-negative and p53-positive subtypes. However, p53 appears to have no influence on OS2. In Cox regression analysis, p53 expression and TNM stage were predictive factors of DFS. In the multivariate analysis, p53 expression and the duration of DFS correlated with OS1, but not for OS2. Taken together, our data indicate p53 showing predicting role in OS1 for VMBC, but not for OS2.
By P. Yang,                                                C. W. Du,          M. Kwan,        S. X. Liang     & G. J. Zhang. In Nature                                                                           

Nano Scientists Reach Holy Grail in Label-Free Cancer Marker Detection: Single Molecules
Just months after setting a record for detecting the smallest single virus in solution, researchers at the Polytechnic Institute of New York University (NYU-Poly) have announced a new breakthrough: They used a nano-enhanced version of their patented microcavity biosensor to detect a single cancer marker protein, which is one-sixth the size of the smallest virus, and even smaller molecules below the mass of all known markers.
In Science Daily (press release)                       

Protein Linked to Cancer Growth May Lead to Cure
Researchers believe the protein could help improve immunotherapy treatments.
By Allie Bidwell. In U.S. News & World Report

Cancer : une stratégie pour affamer les tumeurs
Les cellules tumorales, qui se divisent rapidement, ont de gros besoins en nutriments et peinent à les trouver. Une équipe britannique vient de découvrir comment elles s'adaptent à ce stress nutritionnel permanent. Ce mécanisme, bâti autour de la protéine EEF2K, pourrait devenir la cible de traitements qui feraient mourir de faim les cellules cancéreuses.
Par Agnès Roux. Dans Futura Sciences

Des cancers du poumon liés à la pollution atmosphérique
Le cancer du fumeur pourrait aussi être lié à la pollution atmosphérique. Bien que le tabac reste le principal facteur de risque de cancer du poumon, une vaste étude vient de montrer que les microparticules retrouvées dans l’air ambiant étaient fortement associées au développement de tumeurs pulmonaires.
Par Janlou Chaput. Dans Futura Sciences

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