vendredi 30 septembre 2011

Antibody cancer drugs in development – Anticorps en développement comme thérapie anticancéreuse




The phase number (http://en.wikipedia.org/wiki/Clinical_trial) refers to the highest clinical phase found in the broad literature.           

Le numéro de phase (http://fr.wikipedia.org/wiki/Essai_clinique) se réfère à la phase clinique la plus élevée identifiée dans la littérature générale.









Research Code
Species
Tradename
Target (antigen)






17-1A
mouse
Panorex
4
CD326 (EpCAM)






7E11-C5.3 (CYT-351)
mouse
Prostascint
4
PSMA






88bv59
human
HumaSPECT
4
Cytokeratin tumor-associated antigen






ABX-EGF (E7,6,3)
human
Vectibix
4
EGFR






B72.3 (CYT-099)
mouse
OncoScint
4
tumor-associated gp72






Campath-1H (LDP-03)
humanized
Campath MabCampath
4
CD52






CDP-771 (CMC-676, CMA-676)
humanized
MyloTarg
4
CD33






GSK-1841157 (HuMax-CD20 2F2)
human
Arzerra
4
CD20






IDEC-C2B8 (R-105 IDEC-102,
RG-105)
chimeric
MabThera Rituxan
4
CD20






IDEC-In2B8 (IDEC-Y2B8 IDEC-129)
mouse
Zevalin
4
CD20






IMC-225 (IMC-C225)
chimeric
Erbitux
4
EGFR






OC-125
mouse
Inadmacis-125
4
MUC16 (CA125)






R-597 (4D5v8)
humanized
Herceptin
4
ErbB2 (HER2)






SGN-35 (cAC10-vcMMAE)
chimeric
Adcetris
4
CD30 (TNFRSF8)






TNFR-immunoadhesin

Enbrel
4
TNFa








Amevive
4
CD2







rat/mouse hybrid
Removab
4
CD326 (EpCAM) + CD3E







mouse
Bexxar
4
CD20






IMMU-4Fab'-Tc99m
mouse
CEA-Scan
4
CEA







mouse
Verluma
4
gp40 carcinoma-associated antigen







mouse
Bexxar
4
CD20






ACA-125 (MEN-2234)
mouse

3
MUC16 (CA125)






AMG-412 (hLL2)
humanized
LymphoCide
3
CD22






AMG-479
human

3
CD221 (IGF1R)






AVE0005 (VEGF Trap)


3
VEGF






BEC2
mouse

3
CD3 ganglioside






CNTO-328 (CLLB8)
chimeric

3
IL6






CP-751871
human

3
CD221 (IGF1R)






GA-101 (RO 5072759 huMAB<CD20> , afutuzumab)
humanized

3
CD20






HuMax-EGFr (2F8)
human

3
EGFR






IMC-11F8 (11F8)
human

3
EGFR






IMMU-LL2
mouse
LymphoScan
3
CD22






mAb-B43.13 (Oregovamab)
mouse
OvaRex
3
MUC16 (CA125)






MORAb-003 (M3)
humanized

3
FOLR1 (folate receptor alpha)






PF-05208773 (WAY-207294 CMC-544)
humanized

3
CD22






RG-1273 (RhuMAb-2C4)
humanized
OmniTarg
3
ErbB2 (HER2)






RG-1549 (HMFG1, R-1549)
mouse
Theragyn
3
CD227 (MUC1)






SGN-33 (Hum-195, Huma-195-gelonin)
humanized
Zamyl
3
CD33






SPECIFID (FavId)
mouse

3
B-lymphoma cell






T-DM1



3
ErbB2 (HER2)






TheraCIM-hR3 (hR3,
Theraloc)
humanized
Theraloc Theracim
3
EGFR






WX-G250 (CA9-SCAN cG250)
chimeric
Rencarex
3
Carbonic Anhydrase IX






ABR-214936
mouse
Anyara
2
TPBG (5T4 oncofetal antigen)






ABR-217620 (Anyara, TTS CD3)
mouse

2
TPBG (5T4 oncofetal antigen)






AMG-102
human

2
HGF






AMG-108

human

2
IL1 system






AMG-145



2
PCSK9






AMG-655 (TRAIL-R2mAb XG1-048)
human

2
CD262 (DR5)






Ch3G4 (Tarvacin)
chimeric

2
phosphatidylserine






CNTO-95
human

2
Integrin alpha5






CR-011-vcMMAE (CDX-011)
human

2
GPNMB






CT-011



2
PD-1 receptor






CYT-356 (90Y)

mouse
Oncoltad
2
PSMA






EMD-273063

humanized

2
Ganglioside GD2






EMD-273066 (KSA-Interleukin-2, huKS-IL2)
humanized

2
CD326 (EpCAM)






EMD-72000
humanized

2
EGFR






F16IL2

human

2
Tenascin-C






hAFP-31
humanized
AFP-Cide
2
AFP (alpha-fetoprotein)






HGS-ETR1 (TRM-1)
human

2
CD261 (DR4)






hMN-14
humanized
CEA-CIDE
2
CEA






IMC-3G3
human

2
PDGFR-alpha






IMC-A12
human

2
CD221 (IGF1R)






IMGN-242 (huC242-DM4)
Cantuzumab Ravtansine
humanized

2
MUC1 isoform (CanAg)






IMGN-901 (huN901-DM1, BB-10901)
humanized

2
CD56 (NCAM)






IMMU-106 (hA20)
humanized

2
CD20






IMMU-107 (hPAM-DOTA hY-PAM4)
humanized

2
CD227 (MUC1)






IMMU-115 (hLL1)
humanized

2
CD74 (MHC class II invariant chain)






MDX-060
human

2
CD30 (TNFRSF8)






MEDI-538 (MT-103, BITE MT-103,, bscCD19xCD3)
human

2
CD19 + CD3E






MK-0646
humanized

2
CD221 (IGF1R)






MORAb-009
chimeric

2
Mesothelin






MT-201
human

2
CD326 (EpCAM)






PRO-95780 (anti-DR5 rhuMAb-DR5)
human

2
CD262 (DR5)






RAV-12

chimeric

2
RAAG12






SB-408075 (huC242-DM1)
humanized

2
MUC1 isoform (CanAg)






SCH-717454 (19D12)
human

2
CD221 (IGF1R)






SCH-900105 (AV-299)
humanized

2
HGF






SGN-40 (huS2C6)
humanized

2
CD40






ST-2146
mouse

2
Tenascin C






STX-100

humanized

2
integrin alpha5-beta6






TRA-8 (CS-1008)
humanized

2
CD262 (DR5)







rat/mouse hybrid
Rexomun
2
ErbB2 (HER2) + CD3E






AS-1402 (huHMFG-1)
humanized

1
CD227 (MUC1)






BIWA-1-DM1
humanized

1
CD44






CAT-8015 (HA-22)
mouse

1
CD22






ETR2-ST01 (HGS-1018, HGS-ETR2)
human

1
CD262 (DR5)






HCD-122 (CHIR-12.12)
human

1
CD40






HeFi-1



1
CD30 (TNFRSF8)






IMC-20D7S
human

1
gp75






IMC-RON8
human

1
Ron receptor






mAb-35 (ZCE-025)
mouse
Hybri-CEAker
1
CEA






MLN-2704 (MLN-591DM1)

humanized

1
PSMA






NPC-1C
chimeric

1
MUC5AC






PDL-063 (huLuc63)
humanized

1
CD319 (CS1)






PDL-192
humanized

1
CD266 (TWEAKR)






PF-04605412



1
Integrin - alpha5-beta1






RG-3502 (Trastuzumab-MCC-DM1 T-DM1
PRO-132365)
humanized

1
ErbB2 (HER2)






RO-4858696
human

1
CD221 (IGF1R)






VB4-845
humanized
Proxinium
Vicinium
1
CD326 (EpCAM)






VB6-485
humanized

1
CD326 (EPCAM)






VB6-845

humanized

1
CD326 (EpCAM)







mouse

1
GM3







chimeric

1
EGFR (ErbB1, HER1)







human

1
CD38







mouse

1
CD227 (MUC1)







mouse

1
episialin






BAY-86-5128
mouse

1
CD20







mouse

1
TAG-72







mouse

1
Colorectal tumor antigen C242







mouse

1
adenocarcinoma antigen







human

1
Vimentin







humanized

1
FAP







mouse

1
CD19






PRO-143996 (MetMAb)
humanized


Scatter factor receptor (MET)







chimeric


Syndecan-1






1 commentaire:

  1. Hello,

    Thank you very much for your ideas to post comments. Monoclonal antibody drugs are a relatively new innovation in cancer treatment, these are available for treating certain cancers, it is the best way to use these new drugs always clear...

    pSIVA

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