The regulation of cancerous tumor
development is converged upon by multiple pathways and factors. Besides
environmental factors, gastrointestinal (GI) tract cancer can be caused by
chronic inflammation, which is generally induced by bacteria, viruses, and
parasites. The role of these inducers in cancer development, cell
differentiation and transformation, cell cycle deregulation, and in the
expression of tumor-associated genes cannot be ignored. Although Helicobacter
pylori activates many oncogenic pathways, particularly those in gastric and
colorectal cancers, the role of viruses in tumor development is also
significant. Viruses possess significant oncogenic potential to interfere with
normal cell cycle control and genome stability, stimulating the growth of
deregulated cells. An increasing amount of recent data also implies the
association of GI cancers with bacterial colonization and viruses. This review
focuses on host-cell interactions that facilitate primary mechanisms of
tumorigenesis and provides new insights into novel GI cancer treatments.
Source: Pathogen-driven gastrointestinal cancers: Time for a change in treatment
paradigm? Alibek
K, Aituov B, Duisembekova A, Bulenova A (abulenova@nu.edu.kz).
Infect Agent Cancer. 2012 Aug 8;7(1):18.
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