The inefficiency of generating
induced pluripotent somatic cells (iPS) engendered two contending models,
namely the Stochastic model and Elite model. Although the former is more
favorable to explain the inherent inefficiencies, it may be fallible to
extrapolate the same working model to reprogramming of cancer cells. Indeed,
tumor cells are known to be inherently heterogeneous with respect to
distinctive characteristics thus providing a suitable platform to test whether
the reprogramming process of cancer cells is biased. Here, we report our
observations that all randomly picked induced pluripotent cancer cells (iPCs)
established previously do not possess mutations known in the parental
population. This unanticipated observation is most parsimoniously explained by
the Elite model, whereby putative early tumor progenies were selected during
induction to pluripotency.
Source: Elite Model for the Generation
of Induced Pluripotent Cancer Cells (iPCs). Lai J, Kong CM, Mahalingam D, Xie
X, Wang X (bchwxy@nus.edu.sg. PLoS One.
2013;8(2):e56702.
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