mercredi 27 février 2013

Focus: Elite Model for the Generation of Induced Pluripotent Cancer Cells (iPCs).





The inefficiency of generating induced pluripotent somatic cells (iPS) engendered two contending models, namely the Stochastic model and Elite model. Although the former is more favorable to explain the inherent inefficiencies, it may be fallible to extrapolate the same working model to reprogramming of cancer cells. Indeed, tumor cells are known to be inherently heterogeneous with respect to distinctive characteristics thus providing a suitable platform to test whether the reprogramming process of cancer cells is biased. Here, we report our observations that all randomly picked induced pluripotent cancer cells (iPCs) established previously do not possess mutations known in the parental population. This unanticipated observation is most parsimoniously explained by the Elite model, whereby putative early tumor progenies were selected during induction to pluripotency.

Source: Elite Model for the Generation of Induced Pluripotent Cancer Cells (iPCs). Lai J, Kong CM, Mahalingam D, Xie X, Wang X (bchwxy@nus.edu.sg. PLoS One. 2013;8(2):e56702.
Free paper available at:


Anticancer compounds: summary (Februar 2013) - Composés anticancéreux (février 2013)




Generic Name
Nom générique
Designation
Brand Name
Nom commercial



Abagovomab


Abexinostat (hydrochloride)
PCI-24781
CRA-024781

Abiraterone acetate
CB7630
Zytiga
Adecatumumab


Aderbasib
INCB 007839

Afatinib
BIBW2992
Tovok
Aflibercept
AVE0005
VEGF Trap
VEGF-Trap
NSC 724770
Zaltrap
Afutuzumab


Agatolimod
PF-3512676

Alacizumab


Alemtuzumab

Campath
Alisertib
MLN8237-004

Altumomab


Alvespimycin
KOS-1022

Alvespimycin hydrochloride
BMS-826476

Alvocidib
Flavopiridol
HL-275
HMR-1275
L86-8275
MDL-107826A
NSC-649890

Amatuximab
MORAb-009

Amonafide ???


Amrubicin hydrochloride
SM-5887

Amuvatinib
MP-470
MP470
HPK-56
MP470.HCl

Anamorelin hydrochloride
RC-1291 HCl

Anatumomab


Angiopoietin-2
REGN910 SAR307746

Apatinib
YN968D1

Apaziquone
EO9
EOquin, Neoquin
Apolizumab


Apricoxib
TG01
R-109339
CS-706

Arcitumomab


Astuprotimut-R
GSK-249553
SB-249553
MAGE-A3 ASCI

Axitinib
AG-13736
AG-013736

Azacitidine

Vidaza
Azacitidine 5’ elaidic ester
CP-4200

Bafetinib
INNO-406
NS-187

Balamapimod
MKI-833

Bardoxolone
RTA 401
CDDO

Bardoxolone methyl
RTA 402
CDDO-Me
NSC 713200

Bavituximab
3G4
Tarvacin
Bectumomab


Belagenpumatucel-L

Lucanix
Belimumab


Belinostat
PXD101
NSC 726630

Belotecan hydrochloride
CKD-602

Berubicin hydrochloride
RTA 744
WP744

Besilesomab


Bevacizumab

Avastin
Bivatuzumab mertansine


Blinatumomab
MEDI-538
MT-103
MT103

Bortezomib

Velcade
Bosutinib
SKI-606
PF-5208763
SKI-758

Brentuximab vedotin
SGN-35
SGN35
cAC10-vcMMAE
Adcetris
Brivanib
BMS-540215

Brivanib alaninate
BMS-582664

Cabazitaxel
XRP-6258

Cabozantinib (s-malate)
XL184
XL 184
EXEL-7184
BMS 907351

Calaspargase (pegol)
EZN-2285

Camptothecin
IT-101
CRLX101
Cyclosert-CPT
Canertinib
CI-1033

Cantuzumab mertansine


Cantuzumab ravtansine
huC242-DM4 IMGN242

Capromab pendetide


Carfilzomib
PR-171

Carlecortemcel-l

StemEX
Carlumab
CNTO 888

Catumaxomab


Cediranib (maleate)
AZD2171 (maleate)
Recentin
Cenersen sodium
OL(1)p53, EL625

Cetuximab

Erbitux
Cevipabulin (fumarate or succinate)
TTI-237

Chidamide
HBI-8000
CS055

Cilengitide
EMD 121974
EMD121974

Citatuzumab bogatox


Cixutumumab
IMC-A12

(Yttrium Y90) Clivatuzumab tetraxetan
hPAM4-DOTA
IMMU-107
90hY-PAM4

Conatumumab
AMG 655
TRAIL-R2 mAb

Contusugene ladenovec
Ad5CMV-p53
INGN 201

Cordecepin or Cordycepin
BU-01
OVI-123

Cositecan
Karenitecin

BNP1350


Crenolanib (besylate), formerly plarotinib
ARO-002(-26)
CP-868,596(-26)
CP-868596, ARO-002

Crisantaspase, Erwinia chrysanthemi L-asparaginase

Erwinase, Erwinaze (USA)
Crizotinib
PF-2341066
PF-2,341,066
PF-02341066
PF1066
PF-1066
Xalkori
Crolibulin
EPC2407

Custirsen sodium
OGX-011
ISIS 112989

Cytarabine:daunorubicin
CPX-351

Dabrafenib (mesylate)
GSK-2118436(B)

Dacetuzumab
SGN-40
huS2C6

Dacomitinib
PF-299
PF299804
PF-00299804
PF-299,804, PF00299804

Dalantercept
ACE-041

Dalotuzumab
MK-0646

Danusertib
PHA-739358

Darinaparsin
ZIO-101

Dasatinib
BMS-354825
Sprycel
Daunorubicin citrate liposome
NSC 82151
DaunoXome
DCVax-Brain

DCVax-L Brain
Decitabine

Dacogen
Defibrotide


Deforolimus
???

Degarelix acetate
FE200486
Firmagon
Delanzomib
CEP18770
CT47098
NPH007098

Demcizumab
OMP-21M18

Denenicokin
L-methionyl(human interleukin-21)
IL-21
rIL-21
recombinant human interleukin 21

Denibulin hydrochloride
MN- 029

Denosumab


Desmethyl Erlotinib
OSI-420, CP-473420

Detumomab


Dinaciclib
SCH 727965

Disomotide
MPS-22

Dovitinib
TKI258
CHIR-258

Doxorubicin (zoptarelin)
AN-152
AN 152
ZEN-008
AEZS-108
DOX-LTSL
ThermoDox
Drozitumab
PRO95780
anti-DR5
rhuMAb DR5

Dulanermin
Apo2L/TRAIL
PRO1762
TRAIL/Apo2L
AMG 951
 rhApo2L
RG3639

Dusigitumab


Ecromexumab


Edotecarin
PF-804950

Edrecolomomab


Efatutazone
CS7017
CS-7017

Elacytarabine
CP-4055
Elacyt
Elagolix
NBI-56418

Elagolix sodium
NBI-56418 Na

Elesclomol
STA-4783

Elisidepsin
PM02734
Irvalec
Elotuzumab
HuLuc63
PDL063
PDL-063
BMS-901608

Emepepimut-S
L-BLP25, BLP-25 (formerly BP1-7-KLH), EMD531444
Stimuvax
Enavatuzumab
PDL 192

Eniluracil
GW776C85
ADH300004
Cytefuran
Ensituximab
NPC-1C

Entinostat
MS275
SNDX-275
MS-275

Enzalutamide
MDVN 300 series
MDV3100

Enzastaurin
LY317615

Epetirimod mesylate
851B
S-30563-35-65

Epitinib
HMPL-813

Epratuzumab
Y90 MAb LL2, 90Y-hLL2, IMMU-103, hLL2, hCD22, AMG 412
LymphoCide Y-90
Eribulin mesylate
E7389

Erismodegib
LDE225

Erlotinib

Tarceva
Ertumaxomab


Etaracizumab
Etaratuzumab
MEDI-522
Abegrin
Vitaxin
Everolimus

Afinitor
Falimarev
PANVAC-F
CVAC-301, formerly Panvac-VF

Famitinib


Farletuzumab
MORAb-003

Ficlatuzumab
SCH900105
AV299
AV-299
SCH 900105

Figitumumab
CP-751,871

Flanvotumab
IMC-20DS7

Flumatinib
HHGV678, HH-GV678, HH-GV-678

Folitixorin calcium
ANX-510
CoFactor

Foretinib
GSK1363089G
XL880

Forodesine
BCX-1777
immucillin-H
Fodosine
Fosbretabulin (tromethamine)
combretastatin-A4 phosphate
CA4P
Zybrestat
Fostamatinib
R7935788

Fostamatinib disodium
R788
R-788
R935788 sodium

Fresolimumab
GC1008

Fruquintinib
HMPL-013

Galactomycin
GM-CT-01 (formerly Davanat-1)   
Pro-5FU
Galeterone
TOK-001
VN/124-1
VN/124
SARM/LI

Galgenprostucel-L
CG1940
GVAX™ Prostate
Galiximab


Ganetespib
STA-9090

Ganitumab
AMG 479

Gataparsen (sodium)
LY2181308 heptadecasodium salt

Gefitinib

Iressa
Gemcitabine 5'-elaidic acid ester
CP-4126
O-1.01
CO-101

Gemtuzumab ozogamicin


Girentuximab
WX-G250
cG250
anti-G250, cG250

(Iodine I124) girentuximab
124IcG250
Redectane
Givinostat
ITF2357

Glembatumumab vedotin
CR011-vcMMAE, CDX-011

Glufosfamide
D-19575

Golnerminogene pradenovec
ADgv EGR.TNF.11D

Histrelin
Formerly RL0903
Vantas
Ibritumomab tiuxetan


Icotinib
BPI-2009-H

Icrucumab
IMC-18F1
IMC18F1
LY3012212

Igovomab


Imatinib


Imatinib Mesylate
STI-571, STI571, formerly CGP-57148B
Gleevec (USA, Canada, Israel), Glivec (Europe)
Imetelstat
GRN163L
formerly GRN719

Imgatuzumab


Inalimarev
PANVAC-V
CVAC-301, formerly Panvac-VF

Indatixumab ravtansine


Indibulin
ZIO-301
D-24851

Indisulam
E7070

Ingenol mebutate
PEP-005

Intedanib
BIBF1120

Intetumumab
CNTO-95
CNTO 095
CNTO 95

Iniparib
BSI-201

Inotuzumab ozogamicin


Interferon-alpha 2b

Biphasix
Iobenguane I 131
MIP-120T, Ultratrace MIBG
Azedra, Ultratrace iobenguane I-131
Ioflubenzamide I131
BA-100
MIP-1145

Ipilimumab
MDX-010
MDX-CTLA-4
Yervoy
Iratumumab
MDX-060

Irosustat
BN83495
STX64
667 Coumate

Ispinesib
SB-715992

Labetuzumab


Lansoprazole

PrevOnco
Lapatinib (ditosylate)
572016, GW572016, GW 572016, GSK 572016
Tykerb (USA, EU), Tyverb
Lapuleucel-T
APC8024, BA7072, DN24-02
Neuvenge
Laromustine
VNP40101M, 101M

Lenalidomide
CDC501, CDC-501, CDC-5013, CC5013, CC-5013
Revlimid (formerly Revimid), Lenalidomide-Celgene Europe
Lenvatinib
ER-203492-00

Lenvatinib mesylate
E7080


Lestaurtinib
CEP-701
KT-5555

Leukocyte interleukin injection

Multikine
Leuprolide acetate

Enanton
Lexatumumab


Lexibulin
CYT997

Linifanib
ABT-869
RG3635

Linsitinib
OSI-906
OSI-906AA

Lintuzumab


Litronesib
LY2523355
KF89617

Lonafarnib
SCH66336

Lonaprisan
ZK 230211

Lorvotuzumab mertansine
huN901-DM1, BB-10901TAP, BB-10901, IMGN901

Lucatumumab
CHIR-12.12
HCD-122

Lumiliximab


Mapatumumab


Marizomib
NPI-0052

Masitinib (mesylate)
Masivet
AB1010

Matuzumab


Melphalan

Percutaneous Hepatic Perfusion (PHP)
Milatuzumab
IMMU-115

Mitumomab


Mituprotimut-T
Id/KLH

Mocetinostat
MGCD0103

Mocetinostat dihydrobromide


Mogamulizumab
KW-0761
KM8761

Motesanib (diphosphate)
AMG-706
AMG706

Moxetumomab pasudotox
CAT-8015
HA22

Mubritinib
TAK165

Nacolomab tafenatox


Naptumomab estafenatox


Narnatumab
IMC-RON8
IMC RON-8
RON8

Navitoclax dihydrochloride
ABT-263
RG7423
A-855071.0

Necitumumab
IMC-11F8

Neratinib
HKI-272
PF-05208767

Nesvacumab


Nilotinib
AMN-107
Tasigna
Nimotuzumab


Niraparib
MK-4827

Nivolumab


Nofetumomab merpentan


Obatoclax
GX15-070

Obinutuzumab
Ro-5072759
 huMAB
GA-101
Afutuzumab

Ocaratuzumab


Ofatumumab
GSK1841157
HuMax-CD20
2F2

Olaparib
AZD2281
KU-0059436

Olaratumab
IMC-3G3
IMC3G3

Omacetaxine mepesuccinate
CGX-635
Homoharringtonine

Onartuzumab
PRO143966
MetMAb
RG3638

Oportuzumab monatox


Oregovomab

OvaRex
Orteronel
TAK-700

Oxaliplatin (L-OHP)
1670RB, RP 54780
Eloxatin, Eloxatine, Elplat
Paclitaxel
ANG1005
GRN1005
MBT-0206
EndoT-1
OncoJan
EndoTAG-1
Palifosfamide
IPM
ZIO-201

Panitumumab

Vectibix
Panobinostat
LBH-589
LBH 589
LBH589
NVP-LBH589
LBH489B
LBH489A

Parsatuzumab


Patritumab


Pazopanib

Votrient
Pegdinetanib
BMS-844203
CT-322
CT322
Adnectin, Angiocept, formerly TriNectin
Pelitinib
EKB-569

Pemtumomab


Perifosine
KRX-0401
D-21266

Pertuzumab
RG1273
R1273
2C4
rhuMAb-2C4
Perjeta (formerly Omnitarg)
Pictilisib
GDC-0941

Pidilizumab


Pintumomab


Pixantrone dimaleate
BBR 2778
Pixuvir
Pixantrone
Plinabulin
NPI-2358

Plitidepsin
Dehydrodidemnin B

Aplidin R Aplidine
Ponatinib
AP24534

Pritumumab


Quarfloxin
CX-3543

Quizartinib
AC220
AC010220

Racotumomab
1E10

Radium223 Chloride

Alpharadin
Radretumab


Ramucirumab
IMC-1121b
IMC 1121B
LY3009806

Ranagengliotucel-T

Glionix
Ranpirnase
Formerly P-30 protein
Onconase
Regorafenib
BAY 73-4506

Resminostat
4SC-201
BYK408740

Retaspimycin hydrochloride
IPI-504
MEDI-561

Ridaforolimus
AP23573
MK-8669

Rigosertib sodium
ON 01910.Na
Estybon
Rindopeptimut
PF-04948568
PF4948568
CDX-110
ALT-110

Rilotumumab
AMG 102

Rituximab

Rituxan
Robatumumab
SCH 717454

Romidepsin

Istodax
Ropidoxuridine
IPdR

Rucaparib
AG-14447

Rucaparib phosphate
AG014699
PF01367338

Ruxolitinib (phosphate)
INC424
INCB018424 (salt)

Sagopilone
DE-03757
ZK 219477
SHY03757,
SH-Y03757A
ZK-219477
ZK-epothilone BAY86-5302
ZK-EPO
Salirasib
farnesyl thiosalicylic acid

Samalizumab
ALXN6000

Sapacitabine
CYC682
CS-682

Saracatinib
AZD0530

Saracatanib fumarate
AZD0530 fumarate

Saridegib
IPI-926

Satumomab pendetide


Seliciclib
R-roscovitine CYC-202

Selumetinib
AZD6244
ARRY-142886
ARRY-886

Selumetinib sulfate
AZD6244 Hydrogen Sulfate

Semaxinib
SU5416

Sepantronium (bromide)
YM155

Sibrotuzumab


Siltuximab
CNTO-328

Sivifene
A-007

Solitomab
MT110

Sorafenib (tosylate)
BAY 43-9006 (BAY 54-9085)
Nexavar
Sotatercept
ACE-011

Squalamine
MSI-1256F
Evizon (ophthalmic)

ALT-801, 264scTCR/IL-2, c264scTCR-IL2
STAR/IL-2
Sulfatinib
HMPL-012

Sunitinib

Sutent
Tabalumab


Tacatuzumab tetraxetan


Talactoferrin alfa, talactoferrin


Talimogene Laherparepvec
OncoVEX GM-CSF, OncoVEXGMCSF, OncoVEXGM-CSF,
JS1 34.5-hGMCSF 47- pA-

Tamoxifen citrate

Soltamox
Tandutinib
MLN0518
MLN518
MLN-518
(formerly CT53518, CT-53518)

Tanespimycin
KOS-953

Tasisulam sodium
LY573636


Tasquinimod
ABR-215050
Tumor Angiogenesis Suppression by Quinolines (TASQ)
Teglanirad chloride
GMX1777
EB1627

Telatinib
BAY 57-9352

Telotristat
LP-778902

Temsirolimus

Torisel
Tenatimomab


Tenifatecan
SN2310

Teprotumumab
RO4858696-000

Theliatinib
HMPL-309

Tigatuzumab
R-161460
TRA-8
CS-1008

Tipapkinogene sovacivec
TG-4001
TG4001
MVA-HPV-IL2
R3484
RO5217790

Tipifarnib
R115777
Zarnestra
Tivantinib
ARQ-650RP
ARQ 650RP
ARQ 197
ARQ197

Tivozanib
AV-951
AV951
Formerly KRN-951

Tosedostat
CHR-2797

Tositumomab


Tozasertib lactate
MK-0457
VX-680

Trametinib
GSK1120212

Trastuzumab

Herceptin
Trastuzumab emtansine
PRO132365
trastuzumab-MCC-DM1
T-DM1
Trastuzumab-DM1
R3502
RG3502

Trebananib
AMG-386

Tremelimumab (formerly ticilimumab)
CP-675,206, CP-675, CP-675206

Ublituximab


Urelumab
BMS-663513

Valrubicin
AD32
Valstar, Valtaxin
Vandetanib
ZD6474
AZD6474
AZD-6474
Caprelsa (formerly Zictifa and Zactima)
Varlitinib
ARRY-334543

Varlitinib tosylate
AR00334543
ARRY-334543
ARRY-543

Vatalanib
PTK787

Veltuzumab
IMMU-106

Veliparib
ABT-888, NSC 737664

Veltuzumab
IMMU-106, hA20, hCD20

Vemurafenib
PLX-4032
RG7204
R7204
RO5185426
Zelboraf
Verubulin
MPC-6827
MX-128495
Azixa
Veltuzumab


Vincristine sulfate liposomes for injection (VSLI)

Marqibo (formerly Onco TCS), Vincristine Optisome
Vinflunine ditartrate
BMS-710485
F-12158
Javlor
Vinorelbine tartrate
ANX-530
Formerly SDP-012
Exelbine
Vintafolide
EC145

Vismodegib
GDC-0449
Cur-691
RG3616
HhAntag
Volasertib
BI6727

Volociximab


Volitinib
HMPL-504

Vorinostat

Zolinza
Vosaroxin
SNS-595
SPC-595, Fformerly AG-7352,
Formerly voreloxin

Votumumab


Zalutumumab
HuMax-EGFr
2F8

Zanolimumab


Zatuximab


Zibotentan
ZD4054