This gene encodes a member of the Kruppel-like factor family of transcriptional regulators involved in development and differentiation as well as in growth signaling pathways, apoptosis, proliferation and angiogenesis. KLF6 functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.
Somatic KLF6 mutations have been reported in astrocytoma, glioblastoma and meningioma, nasopharyngeal carcinoma, prostate cancer, colorectal cancer, hepatocellular carcinoma, gastric cancer. Most mutation events are substitutions.
References (open access):
Nucleo-cytoplasmic localization domains regulate Krüppel-like factor 6 (KLF6) protein stability and tumor suppressor function. Rodríguez E, Aburjania N, Priedigkeit NM, DiFeo A, Martignetti JA. PLoS One. 2010 Sep 9;5(9). pii: e12639.