mercredi 28 novembre 2012

Anticancer molecules (99) – Molécules anticancéreuses (99) - AXITINIB


Name: axitinib
Commercial name: Inlyta
Pharmacological class: small tyrosine kinase inhibitor
Therapeutic class: antineoplastic
Action: the orally available axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect.

In 2012, axitinib is approved:

for the treatment of advanced renal cell carcinoma after the failure of one prior systemic therapy.


Nom: axitinib
Nom commercial: Inlyta
Classe pharmacologique: petite molécule inhibitrice de tyrosine kinases
Classe thérapeutique: antinéoplasiques
Action: l’axitinib inhibe l’action des cytokines proangiogéniques “vascular endothelial growth factor” (VEGF) and “platelet-derived growth factor receptor” (PDGF), exerçant par conséquent un effet anti-angiogénique.

En 2012, l’axitinib est approuvé:

pour le traitement du carcinome à cellules rénales avancé, après échec d’une thérapie systémique préalable

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