ABSTRACT:
BACKGROUND: Previous studies have found a link
between a low DNA repair capacity (DRC) level and increased cancer risk. Our
aim was to assess the statistical association of DRC level and breast cancer
(BC) using a case--control epidemiological study in a Hispanic community.
METHODS:
We conducted a comparative observational study
to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico . Over a 6-year period, we compared 285 women
newly diagnosed with BC to 539 without BC. DRC levels were measured in
lymphocytes by means of a host-cell reactivation assay. We assessed the
sensitivity, specificity, and association using the receiver operating
characteristic curve analysis. Multiple logistic regression-adjusted odds
ratios were estimated with 95% confidence level to measure the strength of the
association of DRC and BC after adjusting for all confounders simultaneously.
RESULTS:
Compared to women without cancer, women with BC
showed an average decrease of 60% in their DRC levels (p < 0.001). Validity
of the association of DRC as a measure of BC risk showed a sensitivity of 83.2%
and specificity of 77.6% (p < 0.0001).
CONCLUSIONS:
Our results support the usefulness of DRC level
as a measure of BC risk. Additional studies in other populations are needed to
further verify its usefulness.
Source: The association of DNA Repair
with breast cancer risk in women. A comparative observational study. Matta J (jmatta@psm.edu), Echenique M, Negron E,
Morales L, Vargas W, Gaetan FS, Lizardi ER, Torres A, Rosado JO, Bolaños G,
Cruz JG, Laboy J, Barnes R, Medina SS, Romero A, Martinez R, Dutil J, Suarez E,
Alvarez-Garriga C, Bayona M. BMC Cancer. 2012 Oct 22;12(1):490.
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