mercredi 14 novembre 2012

Focus: Using lithium as a neuroprotective agent in patients with cancer

Neurocognitive impairment is being increasingly recognized as an important issue in patients with cancer who develop cognitive difficulties either as part of direct or indirect involvement of the nervous system or as a consequence of either chemotherapy-related or radiotherapy-related complications. Brain radiotherapy in particular can lead to significant cognitive defects. Neurocognitive decline adversely affects quality of life, meaningful employment, and even simple daily activities. Neuroprotection may be a viable and realistic goal in preventing neurocognitive sequelae in these patients, especially in the setting of cranial irradiation. Lithium is an agent that has been in use for psychiatric disorders for decades, but recently there has been emerging evidence that it can have a neuroprotective effect. This review discusses neurocognitive impairment in patients with cancer and the potential for investigating the use of lithium as a neuroprotectant in such patients.

Source: Using lithium as a neuroprotective agent in patients with cancer. Khasraw M (, Ashley D, Wheeler G, Berk M. BMC Med. 2012 Nov 2;10(1):131.
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1 commentaire:

  1. Chemotherapy one of the standardized regimen for cancer patients. Its function is to target and impair the cancer cells, however during the therapy healthy cells are also being compromised.rate for neurocognitive impairment is now increasing as part of the complication. By using an alternative treatment pancreatic cancer, maybe harsh side effects like these will be lessen.