BACKGROUND: Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear.
We examined a series of 100 lung cancer patients from
for the presence of HPV DNA in both lung tumor specimens and adjacent
non-tumoral specimens from the same patients. Thirty-five of the most
clinically relevant HPV types were assayed using PCR amplification of the
highly conserved L1 region of the viral genome followed by hybridization with
specific probes. UK
No HPV was detected in tumor specimens nor in normal lung tissue of any patient.
These data indicate that, in this Western series, HPV is not associated with the risk of lung cancer. Our findings will help refine estimates of lung cancer risk in patients affected by a common viral infection involved in other types of human cancer.
Source: Testing of human papillomavirus in lung cancer and non-tumor lung tissue. Galvan A, Noci S, Taverna F, Lombardo C, Franceschi S, Pastorino U, Dragani TA. BMC Cancer. 2012 Nov 12;12(1):512.
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