ABSTRACT:
BACKGROUND: In Scotland
METHODS:
Analysis was carried out on 309 cases and 294
controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and
logistic regression models were applied to investigate the association between
statin use and CRC risk and survival.
RESULTS:
In an adjusted logistic regression model,
statins were found to show a statistically significant association for three of
the four statin variables and were found to not show a statistically
significant association with either all-cause or CRC-specific mortality (OR
0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value =
0.12, respectively).
CONCLUSION:
We did find a statistically significant
association between statin intake and CRC risk but not statin intake and
CRC-specific mortality. However, the study was insufficiently powered and
larger scale studies may be advisable.
Source: Statin use and association with colorectal cancer
survival and risk: case control study with prescription data linkage. Lakha F (fatim.lakha@nhs.net), Theodoratou E,
Farrington SM, Tenesa A, Cetnarskyj R, Din FV, Porteous ME, Dunlop MG, Campbell
H. BMC Cancer. 2012 Oct 22;12(1):487.
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