mardi 13 mars 2012

Anticancer molecules (80) – Molécules anticancéreuses (80) - TEMOZOLOMIDE


Name: temozolomide
Commercial names: Methazolastone, Temodar, Temodal
Pharmacological class: alkylating agent
Therapeutic class: antineoplastic
Action: temozolomide is not directly active but undergoes rapid nonenzymatic conversion at physiologic pH to the reactive compound 5-(3-methyltriazen-1-yl)-imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is thought to be primarily due to alkylation of DNA. Alkylation (methylation) occurs mainly at the O6 and N7 positions of guanine.

In 2011, temozolomide is approved:

            ● for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment.


Nom: témozolomide
Noms commerciaux: Methazolastone, Temodar, Temodal
Classe pharmacologique: agent alkylant
Classe thérapeutique: antinéoplasiques
Action: le témozolomide n’agit pas directement, mais subit rapidement une conversion qui donne le composé réactif 5-(3-methyltriazen-1-yl)-imidazole-4-carboxamide (MTIC). La cytotoxicité du MTIC est semble être principalement due à l'alkylation de l’ADN.

En 2011, le témozolomide est approuvé:

            ● pour le traitement des patients adultes atteints de glioblastome multiforme nouvellement diagnostiqué, en association avec la radiothérapie puis en traitement d'entretien.

1 commentaire:

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