mardi 15 novembre 2011

Anticancer molecules (65) – Molécules anticancéreuses (65) - Aprepitant




APREPITANT


Name: aprepitant
Commercial name: Emend
Pharmacological class: substance P/neurokinin 1 (NK1) receptor antagonist
Therapeutic class: adjunctive antiemetic
Action: aprepitant competitively binds with high affinity to the neurokinin 1 (NK1) receptors in the brain, blocking the effect of substance P in the central nervous system (CNS).

In 2011, aprepitant is approved to be used alone or with other drugs to prevent or treat:

            • nausea and vomiting caused by chemotherapy and nausea and vomiting observed after surgery.

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Nom: aprépitant
Nom commercial: Emend
Classe pharmacologique: antagoniste des récepteurs à la substance P/neurokinine 1 (NK1)
Classe thérapeutique: antiémétique adjuvant
Action: L'aprépitant se lie compétititivement avec une haute affinité aux récepteurs à la neurokinine 1 (NK1) présents dans le cerveau, bloquant l'effet de la substance P dans le système nerveux central (SNC).

En 2011, l'aprépitant est approuvé pour une utilisation seul ou avec d'autres médicaments pour prévenir ou traiter:

             • Les nausées et vomissements causés par la chimiothérapie ou consécutifs à la chirurgie.


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