dimanche 25 décembre 2011

Mutated genes in cancer (40) – SOCS1


In databases:

● Entrez (http://www.ncbi.nlm.nih.gov/sites/gquery): 8651 or SOCS1
● Ensembl (http://www.ensembl.org/index.html): ENSG00000185338
● UniProt (http://www.uniprot.org/): O15524
● GeneCards (http://www.genecards.org/): SOCS1
● HGNC (http://www.genenames.org/): 19383 or SOCS1

Gene locus:


Protein name:

Suppressor of cytokine signaling 1

Protein Size:

211 amino acids; about 24 kDa


The protein encoded by SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. Members of this family are cytokine-inducible negative regulators of cytokine signaling. The SOCS1 protein is rapidly induced following stimulation by several type I and type II cytokines (including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamm), and it attenuates their signaling by its ability to bind and inhibit all four of the Janus family of intracellular tyrosine kinases (JAKs).

Cancer-related alterations:

Somatic SOCS1 mutations have been found in tumors from haematopoietic and lymphoid tissue. Mutations in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma are frequent. Deletions as well as point mutations are observed. There are no mutational hot spots.

References (open access):

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G. Aging (Albany NY). 2010 Jul;2(7):445-52.

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function. Palmer DC, Restifo NP. Trends Immunol. 2009 Dec;30(12):592-602.

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