The protein encoded by SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. Members of this family are cytokine-inducible negative regulators of cytokine signaling. The SOCS1 protein is rapidly induced following stimulation by several type I and type II cytokines (including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamm), and it attenuates their signaling by its ability to bind and inhibit all four of the Janus family of intracellular tyrosine kinases (JAKs).
Somatic SOCS1 mutations have been found in tumors from haematopoietic and lymphoid tissue. Mutations in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma are frequent. Deletions as well as point mutations are observed. There are no mutational hot spots.
References (open access):
SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G. Aging (AlbanyNY). 2010 Jul;2(7):445-52.