mercredi 7 décembre 2011

United States Adopted Names Council - Recently adopted name for antitumoral compound (December 2011) - Nom d’antitumoral adopté récemment (décembre 2011)

Name (nom)
Code name (nom de code)

antibody (anticorps)
 SLAM family member 7 (CD2-like receptor activating cytotoxic cells, CD319 antigen), CS1

According to National Cancer Institute (NCI) Drug Dictionary, elotuzumab is a humanized monoclonal antibody directed against the human CS1 (CD2 subset 1, CRACC, SLAMF7) antigen with potential antineoplastic activity. Elotuzumab binds to the CS1 antigen, which may trigger antibody-dependent cellular cytotoxicity (ADCC) in cells expressing CS1. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is highly expressed by multiple myeloma cells, but minimally expressed by normal cells.

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