Anticancer molecules (15) – Molécules anticancéreuses (15)

           

PAZOPANIB

Name: pazopanib hydrochloride

Commercial name: Votrient

Pharmacological class: tyrosine kinase inhibitor

Therapeutic class: antineoplastic

Action: pazopanib is an oral multi-target tyrosine kinase inhibitor of vascular endothelial growth factor receptors (VEGFR-1, 2 and 3), platelet-derived growth factor (PDGFR-α and –β), stem cell factor receptor (c-KIT), fibroblast growth factor receptor (FGFR-1 and 3), interleukin-2 receptor inducible T-cell kinase (Itk), leukocyte specific protein tyrosine kinase (Lck) and transmembrane glycoprotein receptor tyrosine kinase (c-Fms).

In 2011, pazopanib hydrochloride is approved:

            ● for advanced renal cell carcinoma

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Nom: chlorhydrate de pazopanib

Nom commercial: Votrient

Classe pharmacologique: inhibiteur de tyrosine kinases

Classe thérapeutique: antinéoplasiques

Action: le chlorhydrate de pazopanib inhibe de multiples tyrosine kinases (VEGFR-1, 2 et 3, PDGFR-α et –β, c-KIT, FGFR-1 et 3, ITK, Lck, c-FMS), et par là-même la croissance des tumeurs.

 En 2011, le chlorhydrate de pazopanib est approuvé :

            ● pour le traitement du carcinome rénal avancé